A message left behind by the Kai Opaka gives Commander Benjamin Sisko a fateful mission: find a young Bajoran girl destined to be a great healer who could bring together the warring factions of Bajor. While Lt. Dax tries to find the healer, Dr. Bashir goes planetside to treat a rare disease that is killing the children in Bajor's resettlement camps.

Surrounded by thousands of dying children, Bashir goes A.W.O.L. from Deep Space Nine, vowing not to return until the plague has been stopped. But by the time Dax finds the girl from the Kai's prophecy the child has fallen victim to the plague. Now, with the fate of the entire planet at stake, Commander Sisko must find Dr. Bashir in time to save the child who may be Bajor's last chance for peace.